| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
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| Autores: |
Abrahamsohn,I.A.
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| Data: |
1998-01-01
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| Ano: |
1998
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| Palavras-chave: |
Trypanosoma cruzi
Interferon-gamma
Interleukin-12
TNF-alpha
Interleukin-10
Innate immunity
Knock-out mice
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| Resumo: |
Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-<FONT FACE="Symbol">a</font>, IFN-<FONT FACE="Symbol">g</font> and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-<FONT FACE="Symbol">g</font> and TNF-<FONT FACE="Symbol">a</font> in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and double RAG/IL-10 KO mice indicating an in vivo regulatory role of IL-10 in innate and T. cruzi-specific immunity are discussed
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100015
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X1998000100015
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.31 n.1 1998
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| Direitos: |
info:eu-repo/semantics/openAccess
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